en-us	Off-label use of medicines for COVID-19 
zh-cn	在核准适应症外使用药品治疗COVID-19 

en-us	No pharmaceutical products have yet been shown to be safe and effective for the treatment of COVID-19. 
zh-cn	迄今尚无经证明可安全有效治疗COVID-19的药品。

en-us	However, a number of medicines have been suggested as potential investigational therapies, many of which are now being or will soon be studied in clinical trials, including the SOLIDARITY trial co-sponsored by WHO and participating countries. 
zh-cn	但有药品被建议作为试验性治疗工具，其中许多药品已被纳入或即将被纳入临床试验研究，包括被纳入世卫组织和参与国共同发起的“团结试验项目”。 

en-us	In many countries, doctors are giving COVID-19 patients medicines that have not been approved for this disease. 
zh-cn	在许多国家，医生对COVID-19患者使用了未获准用于治疗此病的药品。

en-us	The use of licensed medicines for indications that have not been approved by a national medicines regulatory authority is considered “off-label” use. 
zh-cn	使用现有的许可药品治疗未经国家药品监管部门批准的适应症被视为在核准适应症外使用药品。

en-us	The prescription of medicines for off-label use by doctors may be subject to national laws and regulations. 
zh-cn	医生可能需根据国家法规开具在核准适应症外使用的药品的处方。

en-us	All health care workers should be aware of and comply with the laws and regulations governing their practice. 
zh-cn	所有卫生保健工作者都应了解并遵守国家有关法规。

en-us	Further, such prescribing should be done on a case-by-case basis. 
zh-cn	此外，应以个案处理方式根据具体情况开具这类处方。

en-us	Unnecessary stockpiling and the creation of shortages of approved medicines that are required to treat other diseases should be avoided.  
zh-cn	应避免造成经批准的用于治疗其他疾病所需药品的囤积和短缺现象。 

en-us	It can be ethically appropriate to offer individual patients experimental interventions on an emergency basis outside clinical trials, provided that no proven effective treatment exists; it is not possible to initiate clinical studies immediately; the patient or his or her legal representative has given informed consent; and the emergency use of the intervention is monitored, and the results are documented and shared in a timely manner with the wider medical and scientific community.  
zh-cn	在临床试验之外紧急向患者提供实验性干预措施在伦理上可能是适当的，但前提是：尚无经证明有效的治疗；不可能立即开始临床研究；患者或其法律代理人已给予知情同意；对紧急使用干预措施情况进行监控，及时记录并与广泛的医学界和科学界分享这些结果。 

en-us	The decision to offer a patient an unproven or experimental treatment is between the doctor and the patient but must comply with national law. 
zh-cn	为患者提供未经证实的治疗或实验性治疗的决定由医生和患者共同决定，但这一决定必须符合国家法律。

en-us	Where it is possible and feasible for the treatment to be given as part of a clinical trial, this should be done unless the patient declines to participate in the trial.  
zh-cn	如果纳入临床试验进行治疗是可能且可行的，那么，除非患者拒绝参与临床试验，应将此项治疗纳入临床试验。 

en-us	If it is not possible to give the treatment as part of a clinical trial, appropriate records of the use of the medicine must be kept, in compliance with national law, and outcomes for patients should be monitored and recorded. 
zh-cn	如果无法将治疗纳入临床试验，则必须按照本国法律保留药品使用的适当记录，并对患者治疗结果进行监测和记录。 

en-us	If early results from an unproven or experimental treatment are promising, the treatment should be studied in the context of a formal clinical trial to establish its safety, efficacy, risks, and benefits.
zh-cn	如果未经证实的治疗或实验性治疗的早期结果良好，应开展正式临床试验对此项治疗进行研究，以确定其安全性、有效性、风险和益处。