ID 原文 译文
1207 应当注意的是，我们在比对病毒中和试验滴度和发光法IgG抗体定量检测的数据中发现目前的SARS-CoV-2特异性IgG抗体检测不能很好体现血浆实际病毒中和能力，建议首选病毒中和试验，或选择稀释320倍后的血浆总抗体水平检测。 The following should be noted. During the comparison of virus neutralization titer and luminescent IgG antibody quantitative detection, we found that the present SARS-CoV-2 specific IgG antibody detection does not fully demonstrate the actual virus neutralization capability of the plasma. Therefore, we suggested the virus neutralization test as the first choice, or test the overall antibody level with the 320-fold dilution of the plasma.
1208 恢复期血浆临床应用 Clinical Use of the Convalescent Plasma
1209 2.1适应证 2.1 Indication
1210 1）呼吸道病毒检测阳性的重症、危重症COVID-19患者； (1) Severe or critically ill COVID-19 patients tested positive in Respiratory tract test;
1211 2）非重症、危重症患者如存在免疫抑制情况，或病毒核酸检测CT值较低，且出现肺部病灶迅速进展者。 (2) The COVID-19 patients who are not severe or critically ill, but in a state of immunity suppression; or have low CT values in the virus nucleic acid testing but with a rapid disease progression in the lungs.
1212 注：原则上恢复期血浆不建议用于病程超过3周的COVID-19患者， Note: In principle, the convalescent plasma should not be used on COVID-19 patients with disease course exceeding three weeks.
1213 但我们实际临床应用中发现，在病程＞3周且呼吸道样本病毒核酸检测持续阳性的患者中应用恢复期血浆治疗，能起到加快病毒清除，提高患者血液淋巴细胞和NK细胞数量，降低血乳酸水平以及改善肾功能的作用。 But in clinical applications, we found that the convalescent plasma therapy is effective for patients with a disease course exceeding three weeks and whose virus nucleic acid test s continuously to show positive from Respiratory tract s specimen. It can speed up virus clearance, increase the numbers of the plasma lymphocytes and NK cell s, reduce the level of plasma lactic acid, and improve renal functions.
1214 2.2禁忌证 2.2 Contraindication
1215 1）既往血浆输注过敏史，枸橼酸钠、亚甲蓝过敏史； (1) Allergy history of plasma, sodium citrate and methylene blue;
1216 2）自身免疫性疾病病史、选择性IgA缺乏症患者应当经临床医师评估后谨慎使用。 (2) For patients with history of autoimmune system diseases or selective IgA deficiency, the application of convalescent plasma should be evaluated cautiously by clinicians.